Revisiting HBV resistance to entecavir with a phenotypic approach
نویسندگان
چکیده
منابع مشابه
Resistance patterns and response to entecavir intensification among HIV-HBV-coinfected adults with persistent HBV viremia.
combined with Truvada (emtricitabine/ tenofovir). However, there is very limited data on the efficacy of NVP + Kivexa, which seems to be a promising HAART combination for several reasons: very low cost; limited metabolic and lipid disturbances, and low pill burden (3 pills daily now but will reduce to 2 when the new once-daily extended-release NVP formulation becomes available). Provided that a...
متن کاملClonal analysis of the quasispecies of antiviral-resistant HBV genomes in patients with entecavir resistance during rescue treatment and successful treatment of entecavir resistance with tenofovir.
BACKGROUND Clonal analysis of quasispecies of resistant HBV genomes in patients with entecavir (ETV) resistance receiving lamivudine (3TC) plus adefovir (ADV) rescue therapy has never been performed. METHODS A sample of 10 patients with ETV resistance who were switched to 3TC+ADV treatment were analysed for changes in viral quasispecies. Serum samples at baseline, and at months 3 and 6 of 3TC...
متن کاملHBV-associated cryoglobulinemic vasculitis: remission after antiviral therapy with entecavir.
BACKGROUND/AIMS Cryoglobulinemic vasculitis remains an uncommon complication of hepatitis B virus infection. METHODS We report the case of a 40-years old female Chinese patient with chronic hepatitis B developing cryoglobulinemic vasculitis with multiple organ involvement (liver, kidney, and skin) coupled with weakness, arthralgias, haemolytic anaemia, and autoimmune thyroiditis. She received...
متن کاملRevisiting resistance to change at the university An interpretative approach
Generally perceived as a negative phenomenon to overcome, resistance to change (RTC) has been discussed widely in the organization literature. However, opting for a manichean view of RTC seems to be simplistic. In this paper we focus on exploring professors' reactions to change induced by the Bologna reform at the university. Based on 38 in-depth interviews and using Pettigrew's framework (cont...
متن کاملTreatment response and evolution of HBV resistance during lamivudine plus adefovir or entecavir therapy in patients with adefovir-resistant mutants.
BACKGROUND Here, we investigated the treatment response and evolution of HBV resistance during lamivudine (LAM) plus adefovir (ADV) and entecavir (ETV) monotherapy in patients with ADV-resistant mutants. METHODS Of the 53 patients with ADV-resistant mutants, 25 received combined LAM plus ADV therapy (LAM+ADV group) and 28 received ETV monotherapy (ETV group) for at least 12 months (median 24 ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antiviral Research
سال: 2020
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2020.104869